Complexity and Ethics of Gene Editing WHAT IS GENE EDITING? Human Gene Manipulation: Screening GLOBAL FERTILITY NEUROTRANSMITTER DISORDERS SECOND LAW FAT AND LIFE Water and Magic THE RANDOM AND THE STABLE IN CHEMISTRY-BASED LIFE Why Healthcare Cannot Be a Completely Free Market Tutorial on the Regulation of the Pharmaceutical Industry Two Visions for Healthcare How…

Complexity and Ethics of Gene Editing

What does gene editing mean for society? How complex is the procedure? What is the likelihood that mistakes will be made in the process? What happens to discarded embryos?

Confronting Complexity

The book you are seeing on your screen may look like a normal book; it is not. It is a conversation in which you are a participant. The book does not offer pat answers to hard questions. In fact, it barely even gives definition to hard questions. Rather, this book presents that stage in which science is most challenging and, arguably, most interesting—the period of identifying just what the problems and issues are. That is why we solicit your help in writing this story—the story of extreme events in social systems.

The participants in this book-writing enterprise are independent thinkers who wish to understand the forces impinging on social systems and the systems’ often dramatic and extreme responses to those forces. Extreme events, the sudden and discontinuous response of social systems to these forces, are what we for shorthand term X-Events. X-events We imagine the reader to be a person who wants to intelligently manage his or her actions and behaviors in the midst of an X-event—in short, to manage an organization in chaos. And not only manage, but be a beneficiary of that event. Explicitly, we understand that there are no simple answers to social questions. But but there is at least a gestalt that can help an individual anticipate and manage X-events. The program outlined here is to build the gestalt by total immersion in the topic—by examining the issues from many perspectives.


The news is full of commentary on gene editing of humans. What is gene editing? How is it different from GMOs and other types of genetic engineering? What are the ethics? How is the course of human evolution being changed?

What Is Money?

  Hello. My name is Roger Jones and I am coming to you from beautiful downtown Lisbon, Portugal. Last week I met in France with a number of thought leaders from around the world. It was a high-altitude environment, and when I left my head was swimming with new thoughts. I would like to combine…

Why Healthcare Cannot Be a Completely Free Market

The concept of supply and demand is the cornerstone of economic theory. For simple commodities, the theory predicts that the demand for a product decreases as the price of the product increases and consumers are unwilling to pay the higher price. The supply increases as the price increases and suppliers increase production to capture increased profits. The actual price of the product is a compromise between the desires of consumers and the acumen of suppliers.

The Decline and Fall of Globalization

To understand what happened in the recent US Presidential election, we have to go back to the early 1980s. At that time the overall global social mood shot upward, probably as a consequence of growing international financial integration that tended to undermine the age-old paradigm of “international diversification”. As the social mood became ever more positive, feelings that “everyone is a potential friend” grew stronger and drove events toward increasing interdependence, trade, and cooperation. It’s no accident that the European Union was formed during this period, along with the World Economic Forum in Davos. This story is graphically shown in the diagram below, where we see globalization totally flat until the mid ‘80s, where it exploded until around 2008.

Some Modest Proposals

I am a social-media whore. I am awake after midnight fascinated by what people might say next. Now that Mr. Trump won the Presidential election, the future no longer seems to be constrained by civilized precedent. Any proposal is now taken to be credible; even the dismantling of the extremely popular Medicare is on the table.

Business Resilience

In the mid 1860s, mining engineer Fredrik Idestam established two ground wood pulp mills on the Nokianvirta River near Tampere, Finland giving rise to the name of the firm we all know today as Nokia. How that company trans- formed itself from a wood pulp company producing paper products to what was up until a few years ago the world’s largest cell phone manufacturing firm is a circuitous tale. This story is a fascinating account of how alert management can shift the focus of an entire organization in time with changes in the outside world so as to more effectively deploy available resources. At one time or another, Nokia proceeded from the production of paper to producing rubberized cables for telephone and electrical firms, as well as bicycle tires, and rubber boots. In the mid-twentieth century, Nokia expanded its repertoire to include consumer electronics by manufacturing electricity generation machinery, personal computers, and communication equipment. In 1992, the firm decided to abandon consumer electronics and focus solely on the rapidly growing telecommunication sector. This decision sowed the seeds of Nokia’s early dominance of the cell phone business when the company used its expertise to develop the GSM technology, which was later adopted as a de facto standard for mobile telephony in the 1990s. It’s estimated that by 2008 worldwide GSM connections were growing at a rate of over one million per day.